Neural tube closure: cellular, molecular and biomechanical mechanisms E Nikolopoulou, GL Galea, A Rolo, NDE Greene, AJ Copp Development 144 (4), 552-566, 2017 | 486 | 2017 |
Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone … T Sugiyama, LB Meakin, WJ Browne, GL Galea, JS Price, LE Lanyon Journal of bone and mineral research 27 (8), 1784-1793, 2012 | 241 | 2012 |
Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is … GL Galea, LB Meakin, T Sugiyama, N Zebda, A Sunters, H Taipaleenmaki, ... Journal of Biological Chemistry 288 (13), 9035-9048, 2013 | 147 | 2013 |
Sclerostin's role in bone's adaptive response to mechanical loading GL Galea, LE Lanyon, JS Price Bone 96, 38-44, 2017 | 137 | 2017 |
Age‐related impairment of bones' adaptive response to loading in mice is associated with sex‐related deficiencies in osteoblasts but no change in osteocytes LB Meakin, GL Galea, T Sugiyama, LE Lanyon, JS Price Journal of Bone and Mineral Research 29 (8), 1859-1871, 2014 | 108 | 2014 |
Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4 GL Galea, A Sunters, LB Meakin, G Zaman, T Sugiyama, LE Lanyon, ... FEBS letters 585 (15), 2450-2454, 2011 | 107 | 2011 |
Making and shaping endochondral and intramembranous bones GL Galea, MR Zein, S Allen, P Francis‐West Developmental Dynamics 250 (3), 414-449, 2021 | 104 | 2021 |
Estrogen receptor‐α is required for the osteogenic response to mechanical loading in a ligand‐independent manner involving its activation function 1 but not 2 SH Windahl, L Saxon, AE Börjesson, MK Lagerquist, B Frenkel, ... Journal of Bone and Mineral Research 28 (2), 291-301, 2013 | 101 | 2013 |
Biomechanical coupling facilitates spinal neural tube closure in mouse embryos GL Galea, YJ Cho, G Galea, MA Molè, A Rolo, D Savery, D Moulding, ... Proceedings of the National Academy of Sciences 114 (26), E5177-E5186, 2017 | 95 | 2017 |
Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading JS Price, T Sugiyama, GL Galea, LB Meakin, A Sunters, LE Lanyon Current osteoporosis reports 9, 76-82, 2011 | 94 | 2011 |
Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight LB Meakin, T Sugiyama, GL Galea, WJ Browne, LE Lanyon, JS Price Bone 54 (1), 113-117, 2013 | 78 | 2013 |
Estrogen receptors α and β have different gender-dependent effects on the adaptive responses to load bearing in cancellous and cortical bone LK Saxon, G Galea, L Meakin, J Price, LE Lanyon Endocrinology 153 (5), 2254-2266, 2012 | 69 | 2012 |
Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice T Sugiyama, GL Galea, LE Lanyon, JS Price Endocrinology 151 (12), 5582-5590, 2010 | 51 | 2010 |
Integrin-mediated focal anchorage drives epithelial zippering during mouse neural tube closure MA Mole, GL Galea, A Rolo, A Weberling, O Nychyk, SC De Castro, ... Developmental Cell 52 (3), 321-334. e6, 2020 | 49 | 2020 |
Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle GL Galea, LB Meakin, MA Harris, PJ Delisser, LE Lanyon, SE Harris, ... Gene 599, 36-52, 2017 | 48 | 2017 |
Wnt16 is associated with age-related bone loss and estrogen withdrawal in murine bone H Todd, GL Galea, LB Meakin, PJ Delisser, LE Lanyon, SH Windahl, ... PLoS One 10 (10), e0140260, 2015 | 46 | 2015 |
Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice T Sugiyama, LB Meakin, GL Galea, BF Jackson, LE Lanyon, FH Ebetino, ... Bone 49 (1), 133-139, 2011 | 46 | 2011 |
Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos GL Galea, O Nychyk, MA Mole, D Moulding, D Savery, E Nikolopoulou, ... Disease models & mechanisms 11 (3), dmm032219, 2018 | 45 | 2018 |
Estrogen receptors' roles in the control of mechanically adaptive bone (re) modeling GL Galea, JS Price, LE Lanyon BoneKEy reports 2, 2013 | 43 | 2013 |
Morphogenesis of canine Chiari malformation and secondary syringomyelia: disorders of cerebrospinal fluid circulation SP Knowler, GL Galea, C Rusbridge Frontiers in Veterinary Science 5, 171, 2018 | 41 | 2018 |