| IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway DF Lee, HP Kuo, CT Chen, JM Hsu, CK Chou, Y Wei, HL Sun, LY Li, ... Cell 130 (3), 440-455, 2007 | 812 | 2007 |
| ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation JY Yang, CS Zong, W Xia, H Yamaguchi, Q Ding, X Xie, JY Lang, CC Lai, ... Nature cell biology 10 (2), 138-148, 2008 | 789 | 2008 |
| Survival of cancer cells is maintained by EGFR independent of its kinase activity Z Weihua, R Tsan, WC Huang, Q Wu, CH Chiu, IJ Fidler, MC Hung Cancer cell 13 (5), 385-393, 2008 | 572 | 2008 |
| Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and … CC Chen, MP Chow, WC Huang, YC Lin, YJ Chang Molecular pharmacology 66 (3), 683-693, 2004 | 326 | 2004 |
| Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity WC Huang, CC Chen Molecular and cellular biology 25 (15), 6592-6602, 2005 | 309 | 2005 |
| Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB WC Huang, TK Ju, MC Hung, CC Chen Molecular cell 26 (1), 75-87, 2007 | 300 | 2007 |
| Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells WC Huang, YJ Chen, LY Li, YL Wei, SC Hsu, SL Tsai, PC Chiu, ... Journal of Biological Chemistry 286 (23), 20558-20568, 2011 | 204 | 2011 |
| c-Src-dependent tyrosine phosphorylation of IKKβ is involved in tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression WC Huang, JJ Chen, CC Chen Journal of Biological Chemistry 278 (11), 9944-9952, 2003 | 164 | 2003 |
| Induction of Akt activity by chemotherapy confers acquired resistance WC Huang, MC Hung Journal of the Formosan Medical Association 108 (3), 180-194, 2009 | 162 | 2009 |
| P300 acetyltransferase mediates stiffness-induced activation of hepatic stellate cells into tumor-promoting myofibroblasts C Dou, Z Liu, K Tu, H Zhang, C Chen, U Yaqoob, Y Wang, J Wen, ... Gastroenterology 154 (8), 2209-2221. e14, 2018 | 159 | 2018 |
| Tyrosine phosphorylation of I-κB kinase α/β by protein kinase C-dependent c-Src activation is involved in TNF-α-induced cyclooxygenase-2 expression WC Huang, JJ Chen, H Inoue, CC Chen The Journal of Immunology 170 (9), 4767-4775, 2003 | 150* | 2003 |
| Tumor necrosis factor α-induced activation of downstream NF-κB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion: involvement of PKCα, tyrosine … CC Chen, CY Chou, YT Sun, WC Huang Cellular Signalling 13 (8), 543-553, 2001 | 127 | 2001 |
| Beyond NF-κB activation: nuclear functions of IκB kinase α WC Huang, MC Hung Journal of biomedical science 20, 1-13, 2013 | 124 | 2013 |
| HDAC inhibition decreases the expression of EGFR in colorectal cancer cells CW Chou, MS Wu, WC Huang, CC Chen PloS one 6 (3), e18087, 2011 | 123 | 2011 |
| Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel α-methylene-γ-butyrolactone … WC Huang, ST Chan, TL Yang, CC Tzeng, CC Chen Carcinogenesis 25 (10), 1925-1934, 2004 | 119 | 2004 |
| Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT … JJ Chen, WC Huang, CC Chen Molecular biology of the cell 16 (12), 5579-5591, 2005 | 104 | 2005 |
| Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells YJ Chen, WC Huang, YL Wei, SC Hsu, P Yuan, HY Lin, II Wistuba, JJ Lee, ... PloS one 6 (6), e21428, 2011 | 102 | 2011 |
| miRNA-34c-5p inhibits amphiregulin-induced ovarian cancer stemness and drug resistance via downregulation of the AREG-EGFR-ERK pathway SL Tung, WC Huang, FC Hsu, ZP Yang, TH Jang, JW Chang, CM Chuang, ... Oncogenesis 6 (5), e326-e326, 2017 | 91 | 2017 |
| Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma CJ Yen, YJ Lin, CS Yen, HW Tsai, TF Tsai, KY Chang, WC Huang, PW Lin, ... Public Library of Science 7 (7), e41931, 2012 | 85 | 2012 |
| BCRP/ABCG2 inhibition sensitizes hepatocellular carcinoma cells to sorafenib WC Huang, YL Hsieh, CM Hung, PH Chien, YF Chien, LC Chen, CY Tu, ... PLoS one 8 (12), e83627, 2013 | 84 | 2013 |
