Steven Lin
Steven Lin
Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica, Taiwan
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RNA-programmed genome editing in human cells
M Jinek, A East, A Cheng, S Lin, E Ma, J Doudna
elife 2, e00471, 2013
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
V Pattanayak, S Lin, JP Guilinger, E Ma, JA Doudna, DR Liu
Nature biotechnology 31 (9), 839-843, 2013
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
M Jinek, F Jiang, DW Taylor, SH Sternberg, E Kaya, E Ma, C Anders, ...
Science 343 (6176), 2014
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
S Lin, BT Staahl, RK Alla, JA Doudna
elife 3, e04766, 2014
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
K Schumann, S Lin, E Boyer, DR Simeonov, M Subramaniam, RE Gate, ...
Proceedings of the National Academy of Sciences 112 (33), 10437-10442, 2015
Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions
TW Lo, CS Pickle, S Lin, EJ Ralston, M Gurling, CM Schartner, Q Bian, ...
Genetics 195 (2), 331-348, 2013
Biotin synthesis begins by hijacking the fatty acid synthetic pathway
S Lin, RE Hanson, JE Cronan
Nature chemical biology 6 (9), 682-688, 2010
Closing in on complete pathways of biotin biosynthesis
S Lin, JE Cronan
Molecular BioSystems 7 (6), 1811-1821, 2011
Escherichia coli O86 O-Antigen Biosynthetic Gene Cluster and Stepwise Enzymatic Synthesis of Human Blood Group B Antigen Tetrasaccharide
W Yi, J Shao, L Zhu, M Li, M Singh, Y Lu, S Lin, H Li, K Ryu, J Shen, ...
Journal of the American Chemical Society 127 (7), 2040-2041, 2005
Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis
V Agarwal, S Lin, T Lukk, SK Nair, JE Cronan
Proceedings of the National Academy of Sciences 109 (43), 17406-17411, 2012
The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis
S Lin, JE Cronan
Journal of Biological Chemistry 287 (44), 37010-37020, 2012
The wbnH gene of Escherichia coli O86: H2 encodes an α-1, 3-N-acetylgalactosaminyl transferase involved in the O-repeating unit biosynthesis
W Yi, Q Yao, Y Zhang, E Motari, S Lin, PG Wang
Biochemical and biophysical research communications 344 (2), 631-639, 2006
Synthesis of the α, ω-dicarboxylic acid precursor of biotin by the canonical fatty acid biosynthetic pathway
JE Cronan, S Lin
Current opinion in chemical biology 15 (3), 407-413, 2011
TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins
M Li, AA Waheed, J Yu, C Zeng, HY Chen, YM Zheng, A Feizpour, ...
Proceedings of the National Academy of Sciences 116 (12), 5705-5714, 2019
Biosynthesis of complex indole alkaloids: elucidation of the concise pathway of okaramines
CY Lai, IW Lo, RT Hewage, YC Chen, CT Chen, CF Lee, S Lin, MC Tang, ...
Angewandte Chemie International Edition 56 (32), 9478-9482, 2017
Heritable genome editing using TALENs and CRISPR/Cas9 to engineer precise insertions and deletions in evolutionarily diverse nematode species
TW Lo, CS Pickle, S Lin, EJ Ralston, M Gurling, CM Schartner, Q Bian, ...
Genetics 195 (2), 331-348, 2013
Enhanced NK-92 cytotoxicity by CRISPR genome engineering using Cas9 ribonucleoproteins
RS Huang, HA Shih, MC Lai, YJ Chang, S Lin
Frontiers in immunology 11, 1008, 2020
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection
KY Huang, MS Lin, TC Kuo, CL Chen, CC Lin, YC Chou, TL Chao, ...
EMBO molecular medicine 13 (1), e12828, 2021
RNA-programmed genome editing in human cells. elife 2: e00471
M Jinek, A East, A Cheng, S Lin, E Ma, J Doudna
Evolution of a new function in an esterase: simple amino acid substitutions enable the activity present in the larger paralog, BioH
H Flores, S Lin, G Contreras-Ferrat, JE Cronan, E Morett
Protein Engineering, Design & Selection 25 (8), 387-395, 2012
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