An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis K Birsoy, T Wang, WW Chen, E Freinkman, M Abu-Remaileh, DM Sabatini Cell 162 (3), 540-551, 2015 | 1350 | 2015 |
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors S Beyaz, MD Mana, J Roper, D Kedrin, A Saadatpour, SJ Hong, ... Nature 531 (7592), 53-58, 2016 | 802 | 2016 |
Lysosomal metabolomics reveals V-ATPase-and mTOR-dependent regulation of amino acid efflux from lysosomes M Abu-Remaileh, GA Wyant, C Kim, NN Laqtom, M Abbasi, SH Chan, ... Science 358 (6364), 807-813, 2017 | 580 | 2017 |
Physiologic medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase JR Cantor, M Abu-Remaileh, N Kanarek, E Freinkman, X Gao, ... Cell 169 (2), 258-272. e17, 2017 | 539 | 2017 |
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes S Epsztejn-Litman, N Feldman, M Abu-Remaileh, Y Shufaro, A Gerson, ... Nature structural & molecular biology 15 (11), 1176-1183, 2008 | 537 | 2008 |
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate ME Pacold, KR Brimacombe, SH Chan, JM Rohde, CA Lewis, ... Nature chemical biology 12 (6), 452-458, 2016 | 505 | 2016 |
mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient GA Wyant, M Abu-Remaileh, RL Wolfson, WW Chen, E Freinkman, ... Cell 171 (3), 642-654. e12, 2017 | 450 | 2017 |
Fasting activates fatty acid oxidation to enhance intestinal stem cell function during homeostasis and aging MM Mihaylova, CW Cheng, AQ Cao, S Tripathi, MD Mana, ... Cell stem cell 22 (5), 769-778. e4, 2018 | 389 | 2018 |
NUFIP1 is a ribosome receptor for starvation-induced ribophagy GA Wyant, M Abu-Remaileh, EM Frenkel, NN Laqtom, V Dharamdasani, ... Science 360 (6390), 751-758, 2018 | 338 | 2018 |
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 RL Wolfson, L Chantranupong, GA Wyant, X Gu, JM Orozco, K Shen, ... Nature 543 (7645), 438-442, 2017 | 324 | 2017 |
Histidine catabolism is a major determinant of methotrexate sensitivity N Kanarek, HR Keys, JR Cantor, CA Lewis, SH Chan, T Kunchok, ... Nature 559 (7715), 632-636, 2018 | 297 | 2018 |
Maintaining iron homeostasis is the key role of lysosomal acidity for cell proliferation RA Weber, FS Yen, SPV Nicholson, H Alwaseem, EC Bayraktar, M Alam, ... Molecular cell 77 (3), 645-655. e7, 2020 | 191 | 2020 |
Structural basis for the docking of mTORC1 on the lysosomal surface KB Rogala, X Gu, JF Kedir, M Abu-Remaileh, LF Bianchi, AMS Bottino, ... Science 366 (6464), 468-475, 2019 | 165 | 2019 |
The microbiota programs DNA methylation to control intestinal homeostasis and inflammation I Ansari, G Raddatz, J Gutekunst, M Ridnik, D Cohen, M Abu-Remaileh, ... Nature microbiology 5 (4), 610-619, 2020 | 142 | 2020 |
R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response MP Crossley, C Song, MJ Bocek, JH Choi, JN Kousouros, ... Nature 613 (7942), 187-194, 2023 | 135 | 2023 |
Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer M Abu-Remaileh, S Bender, G Raddatz, I Ansari, D Cohen, J Gutekunst, ... Cancer research 75 (10), 2120-2130, 2015 | 112 | 2015 |
MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo EC Bayraktar, L Baudrier, C Özerdem, CA Lewis, SH Chan, T Kunchok, ... Proceedings of the National Academy of Sciences 116 (1), 303-312, 2019 | 97 | 2019 |
Oct‐3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β‐catenin signalling M Abu‐Remaileh, A Gerson, M Farago, G Nathan, I Alkalay, ... The EMBO journal 29 (19), 3236-3248, 2010 | 88 | 2010 |
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia MS Haney, R Pálovics, CN Munson, C Long, PK Johansson, O Yip, ... Nature 628 (8006), 154-161, 2024 | 87 | 2024 |
Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation M Abu-Remaileh, RI Aqeilan Cell Death & Differentiation 21 (11), 1805-1814, 2014 | 79 | 2014 |