| Aspects of the general biology of adenosine A2A signaling BB Fredholm, Y Chern, R Franco, M Sitkovsky Progress in neurobiology 83 (5), 263-276, 2007 | 246 | 2007 |
| A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease HY Hsiao, YC Chen, HM Chen, PH Tu, Y Chern Human molecular genetics 22 (9), 1826-1842, 2013 | 221 | 2013 |
| Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease TC Ju, HM Chen, JT Lin, CP Chang, WC Chang, JJ Kang, CP Sun, ... Journal of Cell Biology 194 (2), 209-227, 2011 | 192 | 2011 |
| CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model SY Chou, YC Lee, HM Chen, MC Chiang, HL Lai, HH Chang, YC Wu, ... Journal of neurochemistry 93 (2), 310-320, 2005 | 189 | 2005 |
| Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease JJ Siew, HM Chen, HY Chen, HL Chen, CM Chen, BW Soong, YR Wu, ... Nature communications 10 (1), 3473, 2019 | 172 | 2019 |
| Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism WC Shen, HY Li, GC Chen, Y Chern, P Tu Autophagy 11 (4), 685-700, 2015 | 162 | 2015 |
| Protein kinase C inhibits adenylyl cyclase type VI activity during desensitization of the A2a-adenosine receptor-mediated cAMP response HL Lai, TH Yang, RO Messing, YH Ching, SC Lin, Y Chern Journal of Biological Chemistry 272 (8), 4970-4977, 1997 | 156 | 1997 |
| Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models YT Lin, Y Chern, CKJ Shen, HL Wen, YC Chang, H Li, TH Cheng, ... PloS one 6 (8), e22924, 2011 | 131 | 2011 |
| Adenosine receptor neurobiology: overview JF Chen, C Lee, Y Chern International review of neurobiology 119, 1-49, 2014 | 130 | 2014 |
| Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage … HC Cheng, HM Shih, Y Chern Journal of Biological Chemistry 277 (37), 33930-33942, 2002 | 118 | 2002 |
| Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease HY Hsiao, FL Chiu, CM Chen, YR Wu, HM Chen, YC Chen, HC Kuo, ... Human molecular genetics 23 (16), 4328-4344, 2014 | 115 | 2014 |
| Dysregulation of C/EBPα by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease MC Chiang, HM Chen, YH Lee, HH Chang, YC Wu, BW Soong, CM Chen, ... Human molecular genetics 16 (5), 483-498, 2007 | 115 | 2007 |
| Activation of protein kinase A and atypical protein kinase C by A2A adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells NK Huang, YW Lin, CL Huang, RO Messing, Y Chern Journal of Biological Chemistry 276 (17), 13838-13846, 2001 | 115 | 2001 |
| Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes SY Chou, JY Weng, HL Lai, F Liao, SH Sun, PH Tu, DW Dickson, Y Chern Journal of Neuroscience 28 (13), 3277-3290, 2008 | 109 | 2008 |
| Regulation of adenylyl cyclase in the central nervous system Y Chern Cellular signalling 12 (4), 195-204, 2000 | 109 | 2000 |
| Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma MC Chiang, CM Chen, MR Lee, HW Chen, HM Chen, YS Wu, CH Hung, ... Human molecular genetics 19 (20), 4043-4058, 2010 | 107 | 2010 |
| Neurovascular abnormalities in humans and mice with Huntington's disease CY Lin, YH Hsu, MH Lin, TH Yang, HM Chen, YC Chen, HY Hsiao, ... Experimental neurology 250, 20-30, 2013 | 105 | 2013 |
| PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease MC Chiang, Y Chern, RN Huang Neurobiology of disease 45 (1), 322-328, 2012 | 104 | 2012 |
| Multiple mechanisms for desensitization of A2a adenosine receptor-mediated cAMP elevation in rat pheochromocytoma PC12 cells. Y Chern, HL Lai, JC Fong, Y Liang Molecular pharmacology 44 (5), 950-958, 1993 | 104 | 1993 |
| Aberrant astrocytes impair vascular reactivity in H untington disease HY Hsiao, YC Chen, CH Huang, CC Chen, YH Hsu, HM Chen, FL Chiu, ... Annals of neurology 78 (2), 178-192, 2015 | 101 | 2015 |
