Jin Chen
Jin Chen
UT Southwestern Medical Center, UCSF, Stanford University
Verified email at
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Pervasive functional translation of noncanonical human open reading frames
J Chen, AD Brunner, JZ Cogan, JK Nuez, AP Fields, B Adamson, ...
Science 367 (6482), 1140-1146, 2020
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
JK Nuez, J Chen, GC Pommier, JZ Cogan, JM Replogle, C Adriaens, ...
Cell 184 (9), 2503-2519. e17, 2021
Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing
JM Replogle, TM Norman, A Xu, JA Hussmann, J Chen, JZ Cogan, ...
Nature biotechnology 38 (8), 954-961, 2020
N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
J Choi, KW Ieong, H Demirci, J Chen, A Petrov, A Prabhakar, SE O'leary, ...
Nature structural & molecular biology 23 (2), 110-115, 2016
Dynamic pathways of− 1 translational frameshifting
J Chen, A Petrov, M Johansson, A Tsai, SE O’leary, JD Puglisi
Nature 512 (7514), 328-332, 2014
Coordinated conformational and compositional dynamics drive ribosome translocation
J Chen, A Petrov, AT Sen, E O'Leary, JD Puglisi
Biophysical Journal 104 (2), 260a, 2013
Structured elements drive extensive circular RNA translation
CK Chen, R Cheng, J Demeter, J Chen, S Weingarten-Gabbay, L Jiang, ...
Molecular cell 81 (20), 4300-4318. e13, 2021
High-throughput platform for real-time monitoring of biological processes by multicolor single-molecule fluorescence
J Chen, RV Dalal, AN Petrov, A Tsai, SE O’Leary, K Chapin, J Cheng, ...
Proceedings of the National Academy of Sciences 111 (2), 664-669, 2014
Standardized annotation of translated open reading frames
JM Mudge, J Ruiz-Orera, JR Prensner, MA Brunet, F Calvet, I Jungreis, ...
Nature biotechnology 40 (7), 994-999, 2022
A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation
YH Lo, KS Kolahi, Y Du, CY Chang, A Krokhotin, A Nair, WD Sobba, ...
Cancer discovery 11 (6), 1562-1581, 2021
Unraveling the dynamics of ribosome translocation
J Chen, A Tsai, SE O’Leary, A Petrov, JD Puglisi
Current opinion in structural biology 22 (6), 804-814, 2012
The dark proteome: translation from noncanonical open reading frames
BW Wright, Z Yi, JS Weissman, J Chen
Trends in Cell Biology 32 (3), 243-258, 2022
Noise of Silicon Nanowire BioFETs
NK Rajan, DA Routenberg, J Chen, MA Reed
IEEE Electron Device Letters 31 (6), 615-617, 2010
Multiple parallel pathways of translation initiation on the CrPV IRES
A Petrov, R Grosely, J Chen, SE O’Leary, JD Puglisi
Molecular cell 62 (1), 92-103, 2016
The dynamics of SecM-induced translational stalling
A Tsai, G Kornberg, M Johansson, J Chen, JD Puglisi
Cell reports 7 (5), 1521-1533, 2014
Kinetic pathway of 40S ribosomal subunit recruitment to hepatitis C virus internal ribosome entry site
G Fuchs, AN Petrov, CD Marceau, LM Popov, J Chen, SE O’Leary, ...
Proceedings of the National Academy of Sciences 112 (2), 319-325, 2015
Coupling of mRNA structure rearrangement to ribosome movement during bypassing of non-coding regions
J Chen, A Coakley, M O’Connor, A Petrov, SE O’Leary, JF Atkins, ...
Cell 163 (5), 1267-1280, 2015
Signal recognition particle-ribosome binding is sensitive to nascent chain length
TR Noriega, A Tsai, MM Elvekrog, A Petrov, SB Neher, J Chen, ...
Journal of Biological Chemistry 289 (28), 19294-19305, 2014
Dynamic recognition of the mRNA cap by Saccharomyces cerevisiae eIF4E
SE O’Leary, A Petrov, J Chen, JD Puglisi
Structure 21 (12), 2197-2207, 2013
Nonfluorescent quenchers to correlate single-molecule conformational and compositional dynamics
J Chen, A Tsai, A Petrov, JD Puglisi
Journal of the American Chemical Society 134 (13), 5734-5737, 2012
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Articles 1–20