追蹤
Yakov Pechersky
Yakov Pechersky
Treeline Biosciences
在 treeline.bio 的電子郵件地址已通過驗證
標題
引用次數
引用次數
年份
Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant
SF Levy, N Ziv, ML Siegal
PLoS Biology 10 (5), e1001325, 2012
4072012
Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations
S Bershtein, W Wu, EI Shakhnovich
Proceedings of the National Academy of Sciences 109 (13), 4857-4862, 2012
1132012
Fragment hits: What do they look like and how do they bind?
F Giordanetto, C Jin, L Willmore, M Feher, DE Shaw
Journal of medicinal chemistry 62 (7), 3381-3394, 2019
742019
Structural mechanism for Bruton’s tyrosine kinase activation at the cell membrane
Q Wang, Y Pechersky, S Sagawa, AC Pan, DE Shaw
Proceedings of the National Academy of Sciences 116 (19), 9390-9399, 2019
572019
The cremeomycin biosynthetic gene cluster encodes a pathway for diazo formation
AJ Waldman, Y Pechersky, P Wang, JX Wang, EP Balskus
ChemBioChem 16 (15), 2172-2175, 2015
382015
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex
J Chen, Q Wang, B Malone, E Llewellyn, Y Pechersky, K Maruthi, ET Eng, ...
Nature structural & molecular biology 29 (3), 250-260, 2022
352022
Ensemble cryo-electron microscopy reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex
J Chen, Q Wang, B Malone, E Llewellyn, Y Pechersky, K Maruthi, ET Eng, ...
bioRxiv, 2021.11. 10.468168, 2021
62021
Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Kα inhibitor that decouples antitumor activity from hyperinsulinemia
A Varkaris, E Pazolli, H Gunaydin, Q Wang, L Pierce, AA Boezio, A Bulku, ...
Cancer Discovery 14 (2), 240-257, 2024
42024
Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Ka inhibitor that decouples anti-tumor activity from hyperinsulinemia.
A Varkaris, E Pazolli, H Gunaydin, Q Wang, L Pierce, AA Boezio, ...
Cancer Discovery, 2023
12023
PI3K-α INHIBITORS AND METHODS OF USE THEREOF
A Boezio, LV Dipietro, CG Fridrich, G Hakan, K Ravi, A Lescarbeau, ...
WO Patent WO2021222556A1, 2021
2021
Back Cover: The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation (ChemBioChem 15/2015)
AJ Waldman, Y Pechersky, P Wang, JX Wang, EP Balskus
ChemBioChem 16 (15), 2254-2254, 2015
2015
Agent-based simulation of bacterial sepsis: a teaching tool for science students
Y Pechersky, K Rasmussen, V Nesdore, Q Mi, Y Vodovotz
Journal of Critical Care 4 (22), 336-337, 2007
2007
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