Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling N Li, Y Xi, HN Tinsley, E Gurpinar, BD Gary, B Zhu, Y Li, X Chen, ... Molecular cancer therapeutics 12 (9), 1848-1859, 2013 | 136 | 2013 |
Persistent polyfunctional chimeric antigen receptor T cells that target glypican 3 eliminate orthotopic hepatocellular carcinomas in mice D Li, N Li, YF Zhang, H Fu, M Feng, D Schneider, L Su, X Wu, J Zhou, ... Gastroenterology 158 (8), 2250-2265. e20, 2020 | 134 | 2020 |
Glypicans as cancer therapeutic targets N Li, W Gao, YF Zhang, M Ho Trends in cancer 4 (11), 741-754, 2018 | 128 | 2018 |
Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma N Li, H Fu, SM Hewitt, DS Dimitrov, M Ho Proceedings of the National Academy of Sciences 114 (32), E6623-E6631, 2017 | 126 | 2017 |
Colon tumor cell growth–inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition HN Tinsley, BD Gary, J Thaiparambil, N Li, W Lu, Y Li, YY Maxuitenko, ... Cancer Prevention Research 3 (10), 1303-1313, 2010 | 94 | 2010 |
A frizzled‐like cysteine‐rich domain in Glypican‐3 mediates Wnt binding and regulates hepatocellular carcinoma tumor growth in mice N Li, L Wei, X Liu, H Bai, Y Ye, D Li, N Li, U Baxa, Q Wang, L Lv, Y Chen, ... Hepatology 70 (4), 1231-1245, 2019 | 93 | 2019 |
Glypican‐3‐specific antibody drug conjugates targeting hepatocellular carcinoma Y Fu, DJ Urban, RR Nani, YF Zhang, N Li, H Fu, H Shah, AP Gorka, ... Hepatology 70 (2), 563-576, 2019 | 86 | 2019 |
A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity JD Whitt, N Li, HN Tinsley, X Chen, W Zhang, Y Li, BD Gary, AB Keeton, ... Cancer prevention research 5 (6), 822-833, 2012 | 82 | 2012 |
Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity N Li, K Lee, Y Xi, B Zhu, BD Gary, V Ramírez-Alcántara, E Gurpinar, ... Oncogene 34 (12), 1499-1509, 2015 | 72 | 2015 |
The role of glypicans in cancer progression and therapy N Li, MR Spetz, M Ho Journal of Histochemistry & Cytochemistry 68 (12), 841-862, 2020 | 64 | 2020 |
Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma L Sun, F Gao, Z Gao, L Ao, N Li, S Ma, M Jia, N Li, P Lu, B Sun, M Ho, ... Journal for Immunotherapy of Cancer 9 (4), 2021 | 63 | 2021 |
β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG K Lee, AS Lindsey, N Li, B Gary, J Andrews, AB Keeton, GA Piazza Oncotarget 7 (5), 5353, 2016 | 61 | 2016 |
A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy E Gurpinar, WE Grizzle, JJ Shacka, BJ Mader, N Li, NA Piazza, S Russo, ... Molecular cancer therapeutics 12 (5), 663-674, 2013 | 52 | 2013 |
Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10 N Li, X Chen, B Zhu, V Ramírez-Alcántara, JC Canzoneri, K Lee, S Sigler, ... Oncotarget 6 (29), 27403, 2015 | 45 | 2015 |
CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice N Li, MB Torres, MR Spetz, R Wang, L Peng, M Tian, CM Dower, ... Cell Reports Medicine 2 (6), 2021 | 35 | 2021 |
Development of highly effective anti-mesothelin hYP218 chimeric antigen receptor T cells with increased tumor infiltration and persistence for treating solid tumors S Tomar, J Zhang, M Khanal, J Hong, A Venugopalan, Q Jiang, ... Molecular cancer therapeutics 21 (7), 1195-1206, 2022 | 33 | 2022 |
Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling B Zhu, A Lindsey, N Li, K Lee, V Ramirez-Alcantara, JC Canzoneri, ... Oncotarget 8 (41), 69264, 2017 | 33 | 2017 |
Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention T Aboul-Fadl, SS Al-Hamad, K Lee, N Li, BD Gary, AB Keeton, GA Piazza, ... Medicinal Chemistry Research 23, 4177-4188, 2014 | 24 | 2014 |
The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer N Li, A Quan, D Li, J Pan, H Ren, G Hoeltzel, N de Val, D Ashworth, W Ni, ... Nature Communications 14 (1), 1986, 2023 | 20 | 2023 |
Advances in immunotherapeutic targets for childhood cancers: A focus on glypican-2 and B7-H3 N Li, MR Spetz, D Li, M Ho Pharmacology & therapeutics 223, 107892, 2021 | 15 | 2021 |