Genetic control of chromatin states in humans involves local and distal chromosomal interactions F Grubert, JB Zaugg, M Kasowski, O Ursu, DV Spacek, AR Martin, ... Cell 162 (5), 1051-1065, 2015 | 368 | 2015 |
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens DW Morgens, M Wainberg, EA Boyle, O Ursu, CL Araya, CK Tsui, ... Nature communications 8 (1), 15178, 2017 | 341 | 2017 |
Measuring the reproducibility and quality of Hi-C data GG Yardımcı, H Ozadam, MEG Sauria, O Ursu, KK Yan, T Yang, ... Genome biology 20, 1-19, 2019 | 107 | 2019 |
Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements J Tycko, M Wainberg, GK Marinov, O Ursu, GT Hess, BK Ego, Aradhana, ... Nature communications 10 (1), 4063, 2019 | 104 | 2019 |
GenomeDISCO: a concordance score for chromosome conformation capture experiments using random walks on contact map graphs O Ursu, N Boley, M Taranova, YXR Wang, GG Yardimci, W Stafford Noble, ... Bioinformatics 34 (16), 2701-2707, 2018 | 97 | 2018 |
Massively parallel phenotyping of coding variants in cancer with Perturb-seq O Ursu, JT Neal, E Shea, PI Thakore, L Jerby-Arnon, L Nguyen, D Dionne, ... Nature biotechnology 40 (6), 896-905, 2022 | 69* | 2022 |
SAMNet: a network-based approach to integrate multi-dimensional high throughput datasets SJC Gosline, SJ Spencer, O Ursu, E Fraenkel Integrative biology 4 (11), 1415-1427, 2012 | 29 | 2012 |
Perspectives on ENCODE F Abascal, R Acosta, NJ Addleman, J Adrian, V Afzal, B Aken, JA Akiyama Nature 583 (7818), 693-699, 2020 | 15 | 2020 |
Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens JE Otto, O Ursu, AP Wu, EB Winter, MS Cuoco, S Ma, K Qian, BC Michel, ... Molecular Cell 83 (8), 1350-1367. e7, 2023 | 11 | 2023 |
Unsupervised learning from noisy networks with applications to hi-c data B Wang, J Zhu, A Pourshafeie, O Ursu, S Batzoglou, A Kundaje Advances in Neural Information Processing Systems 29, 2016 | 7 | 2016 |
Network modelling of topological domains using Hi-C data YXR Wang, P Sarkar, O Ursu, A Kundaje, PJ Bickel The annals of applied statistics 13 (3), 1511, 2019 | 6 | 2019 |
Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens O Ursu, SJC Gosline, N Beeharry, L Fink, V Bhattacharjee, SC Huang, ... Plos one 12 (10), e0185650, 2017 | 4 | 2017 |
Methods and compositions for massively parallel variant and small molecule phenotyping A Regev, P Thakore, J Doench, JT Neal, J Boehm, O Ursu US Patent App. 16/809,458, 2020 | 2 | 2020 |
Massively parallel phenotyping of coding variants in cancer with Perturb-seq (vol 40, pg 896, 2022) O Ursu, JT Neal, E Shea, PI Thakore, L Jerby-Arnon, L Nguyen, D Dionne, ... NATURE BIOTECHNOLOGY 40 (11), 1691-1691, 2022 | | 2022 |
Understanding Gene Regulation and Genetic Variation Through the Lens of Three-Dimensional Genome Architecture O Ursu Stanford University, 2018 | | 2018 |