| An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis K Birsoy, T Wang, WW Chen, E Freinkman, M Abu-Remaileh, DM Sabatini Cell 162 (3), 540-551, 2015 | 1364 | 2015 |
| Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites S Schwartz, MR Mumbach, M Jovanovic, T Wang, K Maciag, GG Bushkin, ... Cell reports 8 (1), 284-296, 2014 | 1230 | 2014 |
| Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells LB Sullivan, DY Gui, AM Hosios, LN Bush, E Freinkman, ... Cell 162 (3), 552-563, 2015 | 1162 | 2015 |
| Lysosomal metabolomics reveals V-ATPase-and mTOR-dependent regulation of amino acid efflux from lysosomes M Abu-Remaileh, GA Wyant, C Kim, NN Laqtom, M Abbasi, SH Chan, ... Science 358 (6364), 807-813, 2017 | 590 | 2017 |
| Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers JR Mayers, ME Torrence, LV Danai, T Papagiannakopoulos, ... Science 353 (6304), 1161-1165, 2016 | 572 | 2016 |
| Physiologic medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase JR Cantor, M Abu-Remaileh, N Kanarek, E Freinkman, X Gao, ... Cell 169 (2), 258-272. e17, 2017 | 546 | 2017 |
| A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate ME Pacold, KR Brimacombe, SH Chan, JM Rohde, CA Lewis, ... Nature chemical biology 12 (6), 452-458, 2016 | 512 | 2016 |
| Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism WW Chen, E Freinkman, T Wang, K Birsoy, DM Sabatini Cell 166 (5), 1324-1337. e11, 2016 | 464 | 2016 |
| mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient GA Wyant, M Abu-Remaileh, RL Wolfson, WW Chen, E Freinkman, ... Cell 171 (3), 642-654. e12, 2017 | 455 | 2017 |
| Fasting activates fatty acid oxidation to enhance intestinal stem cell function during homeostasis and aging MM Mihaylova, CW Cheng, AQ Cao, S Tripathi, MD Mana, ... Cell stem cell 22 (5), 769-778. e4, 2018 | 399 | 2018 |
| SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance D Kim, BP Fiske, K Birsoy, E Freinkman, K Kami, RL Possemato, ... Nature 520 (7547), 363-367, 2015 | 380 | 2015 |
| Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death J Garcia-Bermudez, L Baudrier, EC Bayraktar, Y Shen, K La, ... Nature 567 (7746), 118-122, 2019 | 349 | 2019 |
| Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin DY Gui, LB Sullivan, A Luengo, AM Hosios, LN Bush, N Gitego, ... Cell metabolism 24 (5), 716-727, 2016 | 335 | 2016 |
| Histidine catabolism is a major determinant of methotrexate sensitivity N Kanarek, HR Keys, JR Cantor, CA Lewis, SH Chan, T Kunchok, ... Nature 559 (7715), 632-636, 2018 | 299 | 2018 |
| Store-operated Ca2+ entry controls clonal expansion of T cells through metabolic reprogramming M Vaeth, M Maus, S Klein-Hessling, E Freinkman, J Yang, M Eckstein, ... Immunity 47 (4), 664-679. e6, 2017 | 246 | 2017 |
| Cytoplasmic ATP hydrolysis powers transport of lipopolysaccharide across the periplasm in E. coli S Okuda, E Freinkman, D Kahne Science 338 (6111), 1214-1217, 2012 | 238 | 2012 |
| Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition YD Shaul, E Freinkman, WC Comb, JR Cantor, WL Tam, P Thiru, D Kim, ... Cell 158 (5), 1094-1109, 2014 | 233 | 2014 |
| The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel E Freinkman, SS Chng, D Kahne Proceedings of the National Academy of Sciences 108 (6), 2486-2491, 2011 | 232 | 2011 |
| Metabolic reprogramming of pancreatic cancer mediated by CDK4/6 inhibition elicits unique vulnerabilities J Franco, U Balaji, E Freinkman, AK Witkiewicz, ES Knudsen Cell reports 14 (5), 979-990, 2016 | 211 | 2016 |
| Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export E Freinkman, S Okuda, N Ruiz, D Kahne Biochemistry 51 (24), 4800-4806, 2012 | 174 | 2012 |
