Karl A. Merrick
Karl A. Merrick
Verified email at mit.edu
Title
Cited by
Cited by
Year
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
S Larochelle, KA Merrick, ME Terret, L Wohlbold, NM Barboza, C Zhang, ...
Molecular cell 25 (6), 839-850, 2007
2322007
Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells
KA Merrick, S Larochelle, C Zhang, JJ Allen, KM Shokat, RP Fisher
Molecular cell 32 (5), 662-672, 2008
892008
A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression
MM Schachter, KA Merrick, S Larochelle, A Hirschi, C Zhang, KM Shokat, ...
Molecular cell 50 (2), 250-260, 2013
882013
Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation
KA Merrick, L Wohlbold, C Zhang, JJ Allen, D Horiuchi, NE Huskey, ...
Molecular cell 42 (5), 624-636, 2011
862011
Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways
D Horiuchi, NE Huskey, L Kusdra, L Wohlbold, KA Merrick, C Zhang, ...
Proceedings of the National Academy of Sciences 109 (17), E1019-E1027, 2012
672012
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells
L Wohlbold, KA Merrick, S De, R Amat, JH Kim, S Larochelle, JJ Allen, ...
Public Library of Science 8 (8), e1002935, 2012
662012
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy
IG Cannell, KA Merrick, S Morandell, CQ Zhu, CJ Braun, RA Grant, ...
Cancer cell 28 (5), 623-637, 2015
632015
MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis
L Suarez-Lopez, G Sriram, YW Kong, S Morandell, KA Merrick, ...
Proceedings of the National Academy of Sciences 115 (18), E4236-E4244, 2018
432018
Picosecond-resolution fluorescence lifetime imaging microscopy: a useful tool for sensing molecular interactions in vivo via FRET
W Zhong, M Wu, CW Chang, KA Merrick, SD Merajver, MA Mycek
Optics express 15 (26), 18220-18235, 2007
352007
Why minimal is not optimal: Driving the mammalian cell cycle—and drug discovery—with a physiologic CDK control network
KA Merrick, RP Fisher
Cell cycle 11 (14), 2600-2605, 2012
202012
Putting one step before the other: distinct activation pathways for Cdk1 and Cdk2 bring order to the mammalian cell cycle
KA Merrick, RP Fisher
Cell Cycle 9 (4), 706-714, 2010
202010
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma
SM Bronner, KA Merrick, J Murray, L Salphati, JG Moffat, J Pang, ...
Bioorganic & medicinal chemistry letters 29 (16), 2294-2301, 2019
152019
A virtual cycle: theory and experiment converge on the exit from mitosis
KA Merrick, RP Fisher
F1000 biology reports 2, 2010
42010
Predictive model of palbociclib response reveals indications in which CDK4/6 inhibitor can be a potential combination partner
M Hafner, N Dompe, W Zhou, E Lin, M Durrbaum, A Daemen, MR Junttila, ...
Cancer Research 79 (13 Supplement), 4410-4410, 2019
12019
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy
RA Grant, MS Tsao, IG Cannell, KA Merrick, SM Morandell, CJ Braun, ...
Elsevier, 2014
12014
A CRITICAL PROTEIN KINASE CONTROLS INFLAMMATION, WOUND REPAIR, AND CANCER AT SITES OF INFLAMMATION
L Suarez-Lopez, X De la Rosa, G Sriram, YW Kong, S Morandell, ...
SHOCK 51 (6), 41-42, 2019
2019
Abstract P5-04-26: Identification of preclinical mechanisms driving acquired resistance to endocrine therapy in estrogen-receptor positive (ER+) breast cancer cells
C Ong, A Daemen, K Merrick, T O'Brien, L Friedman, G Hatzivassiliou
Cancer Research 79 (4 Supplement), P5-04-26-P5-04-26, 2019
2019
Identification of preclinical mechanisms driving acquired resistance to endocrine therapy in estrogen-receptor positive (ER plus) breast cancer cells
C Ong, A Daemen, K Merrick, T O'Brien, L Friedman, G Hatzivassiliou
CANCER RESEARCH 79 (4), 2019
2019
P-273 MK2 Inhibition Prevents Colitis-associated Cancer Progression
L Suarez-Lopez, K Merrick, S Morandell, Y Hernandez, K Haigis, M Yaffe
Inflammatory Bowel Diseases 23, 2017
2017
Chemical Genetics Reveals a Specific Requirement for Cdk2 Activity in the DNA Damage Response and Identifies Nbs1 as a Cdk2 Substrate in Human Cells
K Shokat, L Wohlbold, KA Merrick, S De, R Amat, JH Kim, S Larochelle, ...
2012
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Articles 1–20