追蹤
Joseph Lehar
Joseph Lehar
MIT, Owkin, various biotechs and funds
在 alum.mit.edu 的電子郵件地址已通過驗證 - 首頁
標題
引用次數
引用次數
年份
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
VK Mootha, CM Lindgren, KF Eriksson, A Subramanian, S Sihag, J Lehar, ...
Nature genetics 34 (3), 267-273, 2003
107662003
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
J Barretina, G Caponigro, N Stransky, K Venkatesan, AA Margolin, S Kim, ...
Nature 483 (7391), 603-607, 2012
82902012
Next-generation characterization of the cancer cell line encyclopedia
M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ...
Nature 569 (7757), 503-508, 2019
28552019
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response
H Gao, JM Korn, S Ferretti, JE Monahan, Y Wang, M Singh, C Zhang, ...
Nature medicine 21 (11), 1318-1325, 2015
14522015
Multi-target therapeutics: when the whole is greater than the sum of the parts
GR Zimmermann, J Lehar, CT Keith
Drug discovery today 12 (1-2), 34-42, 2007
13172007
Time series analysis with clean-part one-derivation of a spectrum
DH Roberts, J Lehár, JW Dreher
ASTRONOMICAL JOURNAL V. 93, NO. 4/APR, P. 968, 1987 93, 968, 1987
12481987
Synergistic drug combinations tend to improve therapeutically relevant selectivity
J Lehár, AS Krueger, W Avery, AM Heilbut, LM Johansen, ER Price, ...
Nature biotechnology 27 (7), 659-666, 2009
10462009
Systematic discovery of multicomponent therapeutics
AA Borisy, PJ Elliott, NW Hurst, MS Lee, J Lehár, ER Price, G Serbedzija, ...
Proceedings of the National Academy of Sciences 100 (13), 7977-7982, 2003
7732003
Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials
C Fritsch, A Huang, C Chatenay-Rivauday, C Schnell, A Reddy, M Liu, ...
Molecular cancer therapeutics 13 (5), 1117-1129, 2014
5212014
Probing the coevolution of supermassive black holes and galaxies using gravitationally lensed quasar hosts
CY Peng, CD Impey, HW Rix, CS Kochanek, CR Keeton, EE Falco, ...
The Astrophysical Journal 649 (2), 616, 2006
4992006
CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors
SR Vora, D Juric, N Kim, M Mino-Kenudson, T Huynh, C Costa, ...
Cancer cell 26 (1), 136-149, 2014
4702014
Automated deep-neural-network surveillance of cranial images for acute neurologic events
JJ Titano, M Badgeley, J Schefflein, M Pain, A Su, M Cai, N Swinburne, ...
Nature medicine 24 (9), 1337-1341, 2018
4402018
FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection
LM Johansen, JM Brannan, SE Delos, CJ Shoemaker, A Stossel, C Lear, ...
Science translational medicine 5 (190), 190ra79-190ra79, 2013
3952013
Chemical combination effects predict connectivity in biological systems
J Lehár, GR Zimmermann, AS Krueger, RA Molnar, JT Ledell, AM Heilbut, ...
Molecular systems biology 3 (1), 80, 2007
3442007
Dust and extinction curves in galaxies with z> 0: the interstellar medium of gravitational lens galaxies
EE Falco, CD Impey, CS Kochanek, J Lehár, BA McLeod, HW Rix, ...
The Astrophysical Journal 523 (2), 617, 1999
3301999
Pharmacogenomic agreement between two cancer cell line data sets
Cancer Cell Line Encyclopedia Consortium, ...
Nature 528 (7580), 84-87, 2015
2982015
A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity
LM Johansen, LE DeWald, CJ Shoemaker, BG Hoffstrom, ...
Science translational medicine 7 (290), 290ra89-290ra89, 2015
2652015
Hubble Space Telescope observations of 10 two-image gravitational lenses
J Lehár, EE Falco, CS Kochanek, BA McLeod, JA Munoz, CD Impey, ...
The Astrophysical Journal 536 (2), 584, 2000
2612000
The fundamental plane of gravitational lens galaxies and the evolution of early-type galaxies in low-density environments
CS Kochanek, EE Falco, CD Impey, J Lehár, BA McLeod, HW Rix, ...
The Astrophysical Journal 543 (1), 131, 2000
2202000
Combination chemical genetics
J Lehár, BR Stockwell, G Giaever, C Nislow
Nature chemical biology 4 (11), 674-681, 2008
2062008
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