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Lars Eckmann
Lars Eckmann
Verified email at ucsd.edu
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Year
IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
FR Greten, L Eckmann, TF Greten, JM Park, ZW Li, LJ Egan, MF Kagnoff, ...
Cell 118 (3), 285-296, 2004
32332004
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
S Grivennikov, E Karin, J Terzic, D Mucida, GY Yu, S Vallabhapurapu, ...
Cancer cell 15 (2), 103-113, 2009
24522009
A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.
HC Jung, L Eckmann, SK Yang, A Panja, J Fierer, ...
The Journal of clinical investigation 95 (1), 55-65, 1995
14831995
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
SI Grivennikov, K Wang, D Mucida, CA Stewart, B Schnabl, D Jauch, ...
Nature 491 (7423), 254-258, 2012
13702012
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
S Vaishnava, CL Behrendt, AS Ismail, L Eckmann, LV Hooper
Proceedings of the National Academy of Sciences 105 (52), 20858-20863, 2008
12012008
Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing
S Maeda, LC Hsu, H Liu, LA Bankston, M Iimura, MF Kagnoff, L Eckmann, ...
Science 307 (5710), 734-738, 2005
9772005
Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium
DA O’Neil, EM Porter, D Elewaut, GM Anderson, L Eckmann, T Ganz, ...
The Journal of Immunology 163 (12), 6718-6724, 1999
8781999
Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry
L Eckmann, MF Kagnoff, J Fierer
Infection and immunity 61 (11), 4569-4574, 1993
8631993
Epithelial cells as sensors for microbial infection.
MF Kagnoff, L Eckmann
The Journal of clinical investigation 100 (1), 6-10, 1997
8071997
Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
J Lee, JH Mo, K Katakura, I Alkalay, AN Rucker, YT Liu, HK Lee, C Shen, ...
Nature cell biology 8 (12), 1327-1336, 2006
7802006
NF-κB is a negative regulator of IL-1β secretion as revealed by genetic and pharmacological inhibition of IKKβ
FR Greten, MC Arkan, J Bollrath, LC Hsu, J Goode, C Miething, ...
Cell 130 (5), 918-931, 2007
7532007
Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis.
SJ Rasmussen, L Eckmann, AJ Quayle, L Shen, YX Zhang, DJ Anderson, ...
The Journal of clinical investigation 99 (1), 77-87, 1997
6801997
Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8
L Eckmann, HC Jung, C Schürer-Maly, A Panja, E Morzycka-Wroblewska, ...
Gastroenterology 105 (6), 1689-1697, 1993
6481993
Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis
C Zaph, AE Troy, BC Taylor, LD Berman-Booty, KJ Guild, Y Du, EA Yost, ...
Nature 446 (7135), 552-556, 2007
6382007
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease
YI Duan, C Llorente, S Lang, K Brandl, H Chu, LU Jiang, RC White, ...
Nature 575 (7783), 505-511, 2019
5672019
Toll-like receptor 9–induced type I IFN protects mice from experimental colitis
K Katakura, J Lee, D Rachmilewitz, G Li, L Eckmann, E Raz
The Journal of clinical investigation 115 (3), 695-702, 2005
5202005
A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide
LC Hsu, SR Ali, S McGillivray, PH Tseng, S Mariathasan, EW Humke, ...
Proceedings of the National Academy of Sciences 105 (22), 7803-7808, 2008
4962008
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
LC Hsu, J Mo Park, K Zhang, JL Luo, S Maeda, RJ Kaufman, L Eckmann, ...
Nature 428 (6980), 341-345, 2004
4652004
NF-κB is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria
D Elewaut, JA DiDonato, J Mogg Kim, F Truong, L Eckmann, MF Kagnoff
The Journal of Immunology 163 (3), 1457-1466, 1999
4371999
Differential and regulated expression of CXC, CC, and C-chemokines by human colon epithelial cells
SK Yang, L Eckmann, A Panja, MF Kagnoff
Gastroenterology 113 (4), 1214-1223, 1997
4201997
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