| A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease M Björkqvist, EJ Wild, J Thiele, A Silvestroni, R Andre, N Lahiri, ... The Journal of experimental medicine 205 (8), 1869-1877, 2008 | 716 | 2008 |
| Huntingtin and the molecular pathogenesis of Huntington's disease: Fourth in Molecular Medicine Review Series C Landles, GP Bates EMBO reports 5 (10), 958-963, 2004 | 624 | 2004 |
| Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease K Sathasivam, A Neueder, TA Gipson, C Landles, AC Benjamin, ... Proceedings of the National Academy of Sciences 110 (6), 2366-2370, 2013 | 511 | 2013 |
| Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss M Salker, G Teklenburg, M Molokhia, S Lavery, G Trew, T Aojanepong, ... PloS one 5 (4), e10287, 2010 | 484 | 2010 |
| Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation G Teklenburg, M Salker, M Molokhia, S Lavery, G Trew, T Aojanepong, ... PloS one 5 (4), e10258, 2010 | 392 | 2010 |
| Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease C Landles, K Sathasivam, A Weiss, B Woodman, H Moffitt, S Finkbeiner, ... Journal of Biological Chemistry 285 (12), 8808-8823, 2010 | 354 | 2010 |
| Deregulation of the serum-and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure MS Salker, M Christian, JH Steel, J Nautiyal, S Lavery, G Trew, Z Webster, ... Nature medicine 17 (11), 1509-1513, 2011 | 201 | 2011 |
| The HdhQ150/Q150 knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes B Woodman, R Butler, C Landles, MK Lupton, J Tse, E Hockly, H Moffitt, ... Brain research bulletin 72 (2-3), 83-97, 2007 | 198 | 2007 |
| The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients A Neueder, C Landles, R Ghosh, D Howland, RH Myers, RLM Faull, ... Scientific reports 7 (1), 1307, 2017 | 191 | 2017 |
| HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration M Mielcarek, C Landles, A Weiss, A Bradaia, T Seredenina, L Inuabasi, ... PLoS biology 11 (11), e1001717, 2013 | 180 | 2013 |
| Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression A Weiss, U Träger, EJ Wild, S Grueninger, R Farmer, C Landles, ... The Journal of clinical investigation 122 (10), 3731-3736, 2012 | 161 | 2012 |
| Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease CL Benn, C Landles, H Li, AD Strand, B Woodman, K Sathasivam, SH Li, ... Human molecular genetics 14 (20), 3065-3078, 2005 | 154 | 2005 |
| Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation A Zourlidou, T Gidalevitz, M Kristiansen, C Landles, B Woodman, ... Human molecular genetics 16 (9), 1078-1090, 2007 | 112 | 2007 |
| The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development C Landles, S Chalk, JH Steel, I Rosewell, B Spencer-Dene, EN Lalani, ... Molecular Endocrinology 17 (12), 2418-2435, 2003 | 66 | 2003 |
| Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene NR Franich, MA Hickey, C Zhu, GF Osborne, N Ali, T Chu, NH Bove, ... Journal of neuroscience research 97 (12), 1590-1605, 2019 | 39 | 2019 |
| Subcellular localization and formation of huntingtin aggregates correlates with symptom onset and progression in a Huntington’s disease model C Landles, RE Milton, N Ali, R Flomen, M Flower, F Schindler, ... Brain communications 2 (2), fcaa066, 2020 | 37 | 2020 |
| TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models RN Hegde, A Chiki, L Petricca, P Martufi, N Arbez, L Mouchiroud, ... The EMBO journal 39 (17), e104671, 2020 | 36 | 2020 |
| HDAC4 Does Not Act as a Protein Deacetylase in the Postnatal Murine Brain In Vivo M Mielcarek, T Seredenina, MP Stokes, GF Osborne, C Landles, ... PloS one 8 (11), e80849, 2013 | 33 | 2013 |
| Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice DT Bryant, C Landles, AS Papadopoulou, AC Benjamin, JK Duckworth, ... Scientific Reports 7 (1), 11900, 2017 | 29 | 2017 |
| B09 Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HDHQ150 knock-in mouse model of Huntington's disease C Landles, D Smith, A Weiss, S Franklin, D Howland, G Bates Journal of Neurology, Neurosurgery & Psychiatry 83 (Suppl 1), A8-A8, 2012 | 29 | 2012 |
