Alan D. Irvine

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Irwin McLeanEmeritus Professor of Genetic Medicine, University of DundeeVerified email at dundee.ac.uk
Jonathan HourihaneRoyal College of Surgeons in IrelandVerified email at rcsi.ie
Deirdre MMurrayProfessor of Paediatrics, Dept of Paediatrics and Child Health, UCCVerified email at ucc.ie
Professor Carsten FlohrHead, Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, King'sVerified email at kcl.ac.uk
Sara J BrownGrant Chair of Dermatology, Wellcome Trust Senior Clinical Fellow, University of EdinburghVerified email at ed.ac.uk
Louise KennyExecutive Pro Vice Chancellor, Faculty of Health and Life Sciences, University of LiverpoolVerified email at liverpool.ac.uk
Prof Mairead KielyUniversity College CorkVerified email at ucc.ie
Emma Guttman-YasskyProfessor of Dermatology and Immunology, Mount Sinai Medical CenterVerified email at mountsinai.org
Padraic G. FallonSchool of Medicine, Trinity College Dublin, Ireland.Verified email at tcd.ie
Eric SimpsonFrances J. Storrs Medical Dermatology Professor, Dermatology, OHSUVerified email at ohsu.edu
Ivone JakasaUniversity of ZagrebVerified email at pbf.hr
Heather CordellProfessor of Statistical Genetics, Newcastle UniversityVerified email at ncl.ac.uk
Lawrence EichenfieldProfessor of Dermatology and Pediatrics, University of California, San DiegoVerified email at rchsd.org
Joan Alice GeogheganUniversity of BirminghamVerified email at tcd.ie
Jochen SchmittProfessor for social medicine and health services research, Center for Evidence-based HealthcareVerified email at uniklinikum-dresden.de
Christian VestergaardVerified email at post9.tele.dk
thomas illigVerified email at mh-hannover.de
John McGrathMay Dunhill Chair in Cutaneous Medicine, King's College LondonVerified email at kcl.ac.uk
Dmitri WallConsultant Dermatologist at Hair Restoration Blackrock, DublinVerified email at physicians.ie
Thomas WerfelMedizinische Hochschule HannoverVerified email at mh-hannover.de

Alan D. Irvine

Trinity College Dublin; Children's Health Ireland

Verified email at tcd.ie - Homepage

dermatology genodermatoses atopic dermatitis


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Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis CNA Palmer, AD Irvine, A Terron-Kwiatkowski, Y Zhao, H Liao, SP Lee, ... Nature genetics 38 (4), 441-446, 2006	3752	2006
Filaggrin mutations associated with skin and allergic diseases AD Irvine, WHI McLean, DYM Leung New England Journal of Medicine 365 (14), 1315-1327, 2011	1482	2011
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris FJD Smith, AD Irvine, A Terron-Kwiatkowski, A Sandilands, LE Campbell, ... Nature genetics 38 (3), 337-342, 2006	1338	2006
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 A Strange, F Capon, CC Spencer, J Knight, ME Weale, MH Allen, ... Nat Genet 42 (11), 985-990, 2010	1153	2010
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity LC Tsoi, SL Spain, J Knight, E Ellinghaus, PE Stuart, F Capon, J Ding, ... Nature Genetics, 2012	1109	2012
Filaggrin in the frontline: role in skin barrier function and disease A Sandilands, C Sutherland, AD Irvine, WHI McLean Journal of cell science 122 (9), 1285, 2009	1096	2009
Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome S Chavanas, C Bodemer, A Rochat, D Hamel-Teillac, M Ali, AD Irvine, ... Nature genetics 25 (2), 141-142, 2000	1054	2000
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema A Sandilands, A Terron-Kwiatkowski, PR Hull, GM O'Regan, TH Clayton, ... Nature genetics 39 (5), 650-654, 2007	820	2007
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations S Weidinger, T Illig, H Baurecht, AD Irvine, E Rodriguez, A Diaz-Lacava, ... Journal of Allergy and Clinical Immunology 118 (1), 214-219, 2006	776	2006
Filaggrin in atopic dermatitis GM O'Regan, A Sandilands, WHI McLean, AD Irvine Journal of Allergy and Clinical Immunology 122 (4), 689-693, 2008	698	2008
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis JS Ried, J Li, XB Zuo, XD Zheng, XY Yin, LD Sun, MA McAleer, ... Nature genetics 47 (12), 1449-1456, 2015	631	2015
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming PG Fallon, T Sasaki, A Sandilands, LE Campbell, SP Saunders, ... Nature genetics 41 (5), 602-608, 2009	567	2009
Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy SJ Brown, Y Asai, HJ Cordell, LE Campbell, Y Zhao, H Liao, K Northstone, ... Journal of Allergy and Clinical Immunology 127 (3), 661-667, 2011	560	2011
Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease E Rodríguez, H Baurecht, E Herberich, S Wagenpfeil, SJ Brown, ... Journal of Allergy and Clinical Immunology 123 (6), 1361-1370. e7, 2009	546	2009
The multifunctional role of filaggrin in allergic skin disease MA McAleer, AD Irvine Journal of Allergy and Clinical Immunology 131 (2), 280-291, 2013	538	2013
Filaggrin mutations, atopic eczema, hay fever, and asthma in children S Weidinger, M O'Sullivan, T Illig, H Baurecht, M Depner, E Rodriguez, ... Journal of Allergy and Clinical Immunology 121 (5), 1203-1209. e1, 2008	525	2008
The microbiome in patients with atopic dermatitis AS Paller, HH Kong, P Seed, S Naik, TC Scharschmidt, RL Gallo, T Luger, ... Journal of Allergy and Clinical Immunology 143 (1), 26-35, 2019	498	2019
Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship JA Geoghegan, AD Irvine, TJ Foster Trends in microbiology 26 (6), 484-497, 2018	486	2018
Hay–Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63 JA McGrath, PHG Duijf, V Doetsch, AD Irvine, R Waal, KRJ Vanmolkot, ... Human molecular genetics 10 (3), 221-230, 2001	467	2001
Human keratin diseases: the increasing spectrum of disease and subtlety of the phenotype–genotype correlation AD Irvine, WHI McLean British Journal of Dermatology 140 (5), 815-828, 1999	467	1999

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