| Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation HM Wu, NS Tzeng, L Qian, SJ Wei, X Hu, SH Chen, SM Rawls, P Flood, ... Neuropsychopharmacology 34 (10), 2344-2357, 2009 | 207 | 2009 |
| Ribavirin reduces mortality in enterovirus 71–infected mice by decreasing viral replication ZH Li, CM Li, P Ling, FH Shen, SH Chen, CC Liu, CK Yu, SH Chen The Journal of infectious diseases 197 (6), 854-857, 2008 | 179 | 2008 |
| β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway L Qian, H Wu, SH Chen, D Zhang, SF Ali, L Peterson, B Wilson, RB Lu, ... The Journal of Immunology 186 (7), 4443-4454, 2011 | 132 | 2011 |
| Microglial regulation of immunological and neuroprotective functions of astroglia SH Chen, EA Oyarzabal, YF Sung, CH Chu, Q Wang, SL Chen, RB Lu, ... Glia 63 (1), 118-131, 2015 | 127 | 2015 |
| Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GNDF in astroglia B Ossola, N Schendzielorz, SH Chen, GS Bird, RK Tuominen, ... Neuropharmacology 61 (4), 574-582, 2011 | 117 | 2011 |
| Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson’s disease models Q Wang, L Qian, SH Chen, CH Chu, B Wilson, E Oyarzabal, S Ali, ... Brain 138 (5), 1247-1262, 2015 | 111 | 2015 |
| Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells A Kumar, SH Chen, MB Kadiiska, JS Hong, J Zielonka, B Kalyanaraman, ... Free Radical Biology and Medicine 73, 51-59, 2014 | 100 | 2014 |
| Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity D Zhang, X Hu, L Qian, SH Chen, H Zhou, B Wilson, DS Miller, JS Hong Journal of Neuroinflammation 8, 1-14, 2011 | 100 | 2011 |
| Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin‐induced damage SH Chen, HM Wu, B Ossola, N Schendzielorz, BC Wilson, CH Chu, ... British journal of pharmacology 165 (2), 494-505, 2012 | 86 | 2012 |
| Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats SL Chen, PL Tao, CH Chu, SH Chen, HE Wu, LF Tseng, JS Hong, RB Lu Journal of Neuroimmune Pharmacology 7, 444-453, 2012 | 85 | 2012 |
| Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91 phox subunit of NADPH … Q Wang, H Zhou, H Gao, SH Chen, CH Chu, B Wilson, JS Hong Journal of neuroinflammation 9, 1-14, 2012 | 82 | 2012 |
| Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration SH Chen, EA Oyarzabal, JS Hong Current opinion in pharmacology 26, 54-60, 2016 | 81 | 2016 |
| Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase Q Wang, CH Chu, L Qian, SH Chen, B Wilson, E Oyarzabal, L Jiang, S Ali, ... Journal of Neuroscience 34 (37), 12490-12503, 2014 | 79 | 2014 |
| Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation Y Liu, YC Lo, L Qian, FT Crews, B Wilson, HL Chen, HM Wu, SH Chen, ... Neuropharmacology 60 (2-3), 373-380, 2011 | 78 | 2011 |
| A novel role of microglial NADPH oxidase in mediating extra‐synaptic function of norepinephrine in regulating brain immune homeostasis L Jiang, SH Chen, CH Chu, SJ Wang, E Oyarzabal, B Wilson, V Sanders, ... Glia 63 (6), 1057-1072, 2015 | 66 | 2015 |
| Preparation of rodent primary cultures for neuron–glia, mixed glia, enriched microglia, and reconstituted cultures with microglia SH Chen, EA Oyarzabal, JS Hong Microglia: Methods and protocols, 231-240, 2013 | 66 | 2013 |
| Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases Q Wang, CH Chu, E Oyarzabal, L Jiang, SH Chen, B Wilson, L Qian, ... Glia 62 (12), 2034-2043, 2014 | 64 | 2014 |
| Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase L Jiang, X Wu, S Wang, SH Chen, H Zhou, B Wilson, CY Jin, RB Lu, K Xie, ... Journal of Neuroinflammation 13, 1-14, 2016 | 58 | 2016 |
| The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia SL Chen, SY Lee, YH Chang, SH Chen, CH Chu, TY Wang, PS Chen, ... Progress in Neuro-Psychopharmacology and Biological Psychiatry 51, 99-104, 2014 | 58 | 2014 |
| Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment SH Chen, A Pearson, DM Coen, SH Chen Journal of virology 78 (1), 520-523, 2004 | 58 | 2004 |
