In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF … T Nickerson, F Chang, D Lorimer, SP Smeekens, CL Sawyers, M Pollak Cancer research 61 (16), 6276-6280, 2001 | 294 | 2001 |
Cloning and characterization of a novel human histone deacetylase, HDAC8 JJ Buggy, ML SIDERIS, P MAK, DD LORIMER, B MCINTOSH, JM CLARK Biochemical Journal 350 (1), 199-205, 2000 | 278 | 2000 |
Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability G Hecht, L Pestic, G Nikcevic, A Koutsouris, J Tripuraneni, DD Lorimer, ... American Journal of Physiology-Cell Physiology 271 (5), C1678-C1684, 1996 | 164 | 1996 |
Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts G Guaitoli, F Raimondi, BK Gilsbach, Y Gómez-Llorente, E Deyaert, ... Proceedings of the National Academy of Sciences 113 (30), E4357-E4366, 2016 | 157 | 2016 |
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis B Baragaña, B Forte, R Choi, S Nakazawa Hewitt, JA Bueren-Calabuig, ... Proceedings of the National Academy of Sciences 116 (14), 7015-7020, 2019 | 105 | 2019 |
Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract DD Lorimer, RV Benya Biochemical and biophysical research communications 222 (2), 379-385, 1996 | 76 | 1996 |
Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein … A Kryshtafovych, J Moult, P Bales, JF Bazan, M Biasini, A Burgin, C Chen, ... Proteins: Structure, Function, and Bioinformatics 82, 26-42, 2014 | 66 | 2014 |
Location and characterization of the human GRP receptor expressed by gastrointestinal epithelial cells HA Ferris, RE Carroll, DL Lorimer, RV Benya Peptides 18 (5), 663-672, 1997 | 66 | 1997 |
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase SN Hewitt, DM Dranow, BG Horst, JA Abendroth, B Forte, I Hallyburton, ... ACS infectious diseases 3 (1), 34-44, 2017 | 57 | 2017 |
Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R) DD Lorimer, K Matkowskj, RV Benya Biochemical and biophysical research communications 241 (2), 558-564, 1997 | 42 | 1997 |
Fibroblast Contractility without an Increase in Basal Myosin Light Chain Phosphorylation in Wild Type Cells and Cells Expressing the Catalytic Domain of Myosin Light Chain … K Obara, G Nikcevic, L Pestic, G Nowak, DD Lorimer, V Guerriero, ... Journal of Biological Chemistry 270 (32), 18734-18737, 1995 | 37 | 1995 |
A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins DW Begley, D Fox III, D Jenner, C Juli, PG Pierce, J Abendroth, M Muruthi, ... Antimicrobial agents and chemotherapy 58 (3), 1458-1467, 2014 | 31 | 2014 |
Structure of acid deoxyribonuclease A Varela-Ramirez, J Abendroth, AA Mejia, IQ Phan, DD Lorimer, ... Nucleic acids research 45 (10), 6217-6227, 2017 | 30 | 2017 |
Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors DH Haft, PG Pierce, SJ Mayclin, A Sullivan, AS Gardberg, J Abendroth, ... Scientific reports 7 (1), 41074, 2017 | 29 | 2017 |
Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis KK Ojo, RM Ranade, Z Zhang, DM Dranow, JB Myers, R Choi, ... PLOS one 11 (8), e0160350, 2016 | 25 | 2016 |
Expression of a mutant myosin light chain that cannot be phosphorylated increases paracellular permeability S Gandhi, DD Lorimer, P De Lanerolle American Journal of Physiology-Renal Physiology 272 (2), F214-F221, 1997 | 24 | 1997 |
Some of the most interesting CASP 11 targets through the eyes of their authors A Kryshtafovych, J Moult, A Baslé, A Burgin, TK Craig, RA Edwards, ... Proteins: Structure, Function, and Bioinformatics 84, 34-50, 2016 | 21 | 2016 |
Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis DW Begley, TE Edwards, AC Raymond, ER Smith, RC Hartley, ... Acta Crystallographica Section F: Structural Biology and Crystallization …, 2011 | 20 | 2011 |
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba L Tillery, K Barrett, J Goldstein, JW Lassner, B Osterhout, NL Tran, L Xu, ... PLoS One 16 (3), e0241738, 2021 | 17 | 2021 |
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 MA Lowe, A Cardenas, JP Valentin, Z Zhu, J Abendroth, JL Castro, ... Journal of medicinal chemistry 65 (20), 14121-14143, 2022 | 15 | 2022 |