| Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis. TC Hwang, G Nagel, AC Nairn, DC Gadsby Proceedings of the National Academy of Sciences 91 (11), 4698-4702, 1994 | 322 | 1994 |
| Cl-channels in CF: lack of activation by protein kinase C and cAMP-dependent protein kinase TC Hwang, L Lu, PL Zeitlin, DC Gruenert, R Huganir, WB Guggino Science 244 (4910), 1351-1353, 1989 | 285 | 1989 |
| Coupling of CFTR Cl− channel gating to an ATP hydrolysis cycle T Baukrowitz, TC Hwang, AC Nairn, DC Gadsby Neuron 12 (3), 473-482, 1994 | 255 | 1994 |
| Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle KY Jih, TC Hwang Proceedings of the National Academy of Sciences 110 (11), 4404-4409, 2013 | 248 | 2013 |
| Genistein potentiates wild-type and delta F508-CFTR channel activity TC Hwang, F Wang, IC Yang, WW Reenstra American Journal of Physiology-Cell Physiology 273 (3), C988-C998, 1997 | 246 | 1997 |
| Gating of the CFTR Cl− channel by ATP‐driven nucleotide‐binding domain dimerisation TC Hwang, DN Sheppard The Journal of physiology 587 (10), 2151-2161, 2009 | 232 | 2009 |
| The protein kinase A-regulated cardiac CI− channel resembles the cystic fibrosis transmembrane conductance regulator G Nagel, TC Hwang, KL Nastiuk, AC Nairn, DC Gadsbyt Nature 360 (6399), 81-84, 1992 | 211 | 1992 |
| Actions of genistein on cystic fibrosis transmembrane conductance regulator channel gating: evidence for two binding sites with opposite effects F Wang, S Zeltwanger, ICH Yang, AC Nairn, TC Hwang The Journal of general physiology 111 (3), 477-490, 1998 | 204 | 1998 |
| G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects SG Bompadre, Y Sohma, M Li, TC Hwang The Journal of general physiology 129 (4), 285-298, 2007 | 183 | 2007 |
| The CFTR chloride channel of mammalian heart DC Gadsby, G Nagel, T Hwang Annual review of physiology 57 (1), 387-416, 1995 | 169 | 1995 |
| The CFTR ion channel: gating, regulation, and anion permeation TC Hwang, KL Kirk Cold Spring Harbor perspectives in medicine 3 (1), a009498, 2013 | 168 | 2013 |
| Molecular pharmacology of the CFTR Cl− channel TC Hwang, DN Sheppard Trends in pharmacological sciences 20 (11), 448-453, 1999 | 163 | 1999 |
| Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics TC Hwang, RE Koeppe, OS Andersen Biochemistry 42 (46), 13646-13658, 2003 | 162 | 2003 |
| Reduced L-type calcium current in ventricular myocytes from endotoxemic guinea pigs J Zhong, TC Hwang, HR Adams, LJ Rubin American Journal of Physiology-Heart and Circulatory Physiology 273 (5 …, 1997 | 160 | 1997 |
| Direct modulation of secretory chloride channels by arachidonic and other cis unsaturated fatty acids. TC Hwang, SE Guggino, WB Guggino Proceedings of the National Academy of Sciences 87 (15), 5706-5709, 1990 | 157 | 1990 |
| CLC-0 and CFTR: chloride channels evolved from transporters TY Chen, TC Hwang Physiological reviews 88 (2), 351-387, 2008 | 146 | 2008 |
| Structural mechanisms of CFTR function and dysfunction TC Hwang, JT Yeh, J Zhang, YC Yu, HI Yeh, S Destefano Journal of General Physiology 150 (4), 539-570, 2018 | 133 | 2018 |
| Functionally distinct phospho-forms underlie incremental activation of protein kinase-regulated Cl-conductance in mammalian heart. TC Hwang, M Horie, DC Gadsby The Journal of general physiology 101 (5), 629-650, 1993 | 132 | 1993 |
| Deletion of phenylalanine 508 causes attenuated phosphorylation‐dependent activation of CFTR chloride channels F Wang, S Zeltwanger, S Hu, TC Hwang The Journal of physiology 524 (3), 637-648, 2000 | 126 | 2000 |
| Gating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis: quantitative analysis of a cyclic gating scheme S Zeltwanger, F Wang, GT Wang, KD Gillis, TC Hwang The Journal of general physiology 113 (4), 541-554, 1999 | 120 | 1999 |
